Goldblatt David, Borrow Ray, Miller Elizabeth
Immunobiology Unit, Institute of Child Health, Public Health Laboratory Service, Communicable Disease Surveillance Centre, London, United Kingdom.
J Infect Dis. 2002 Feb 1;185(3):397-400. doi: 10.1086/338474. Epub 2002 Jan 10.
The immune response to polysaccharides and conjugate vaccines in adults is poorly understood. This study assessed meningococcal serogroup C responses after AC polysaccharide (MACP) and C conjugate (MCC) vaccine administration in young adults and explored immune memory by measuring antibody avidity. The geometric mean avidity indices (GMAIs) measured 1 month after MACP vaccination were relatively high and failed to increase significantly in the 6 months before and after a second dose of MACP/MCC. Although the GMAI of naive adults increased immediately following MCC vaccination to 215.7 (95% confidence interval, 181.0-257.1), a level similar to that seen after MACP vaccination, no further maturation in the subsequent 6 months was seen. Antibody induced by polysaccharide antigens in adults is already of relatively high avidity (compared with that in infants and toddlers) and fails to mature further, probably because both MACP and MCC predominantly stimulate memory B cells.
成人对多糖疫苗和结合疫苗的免疫反应尚不清楚。本研究评估了年轻成人接种AC多糖疫苗（MACP）和C结合疫苗（MCC）后脑膜炎球菌C群的反应，并通过测量抗体亲和力来探索免疫记忆。MACP疫苗接种后1个月测得的几何平均亲和力指数（GMAIs）相对较高，在第二剂MACP/MCC接种前后6个月内未显著增加。尽管未接种过疫苗的成人在接种MCC后GMAI立即升至215.7（95%置信区间，181.0-257.1），与接种MACP疫苗后的水平相似，但在随后6个月内未进一步成熟。成人中由多糖抗原诱导的抗体已经具有相对较高的亲和力（与婴幼儿相比），并且不会进一步成熟，这可能是因为MACP和MCC主要刺激记忆B细胞。
