Fukuta A, Hara T, Tsurumi H, Moriwaki H
First Department of Internal Medicine, Gifu University School of Medicine.
Rinsho Ketsueki. 2001 Nov;42(11):1145-7.
A 47-year-old man was admitted to our hospital with subcutaneous nodules on the bilateral lower legs and disseminated intravascular coagulation (DIC). Peripheral blood examination revealed leukocytosis with an increase of mature eosinophils, thrombocytopenia and abnormal coagulation. Bone marrow aspiration revealed an increased eosinophil count, and a diagnosis of hypereosinophilic syndrome (HES) was made. Prednisolone (PSL) therapy was not effective. Subsequent methylPSL pulse therapy followed by PSL brought about a transient improvement of the HES and DIC, but after reduction of the PSL, the HES worsened. After addition of cyclosporin A to the PSL, however, the HES improved and did not worsen.
一名47岁男性因双侧小腿皮下结节和弥散性血管内凝血（DIC）入院。外周血检查显示白细胞增多，伴有成熟嗜酸性粒细胞增多、血小板减少和凝血异常。骨髓穿刺显示嗜酸性粒细胞计数增加，诊断为高嗜酸性粒细胞综合征（HES）。泼尼松龙（PSL）治疗无效。随后采用甲泼尼龙冲击治疗，继以PSL治疗，使HES和DIC有短暂改善，但PSL减量后，HES病情恶化。然而，在PSL治疗中加用环孢素A后，HES病情改善且未再恶化。
