Saleemi M A, Ashraf R N, Mellander L, Zaman S
Department of Social and Preventive Paediatrics, King Edward Medical College, Lahore, Pakistan.
Acta Paediatr. 2001 Nov;90(11):1304-8. doi: 10.1080/080352501317130371.
A "nested" case-control design was used to identify cases from a longitudinally followed cohort of 1236 newborns registered during 1984-1987, living in three socioeconomically different areas. The children had a length <-2SDS (standard deviation scores) at 6, 12, 24 and 60 mo of age using the NCHS reference. The controls were matched for gender, area and month of birth. A logistic regression analysis was used for determining the risk factors for stunting at each age. Postnatal linear growth was also examined in these two groups of children and body size was compared with the NCHS reference and that of upper-middle-class children (n = 240). At 6 mo of age, prematurity and duration of breastfeeding showed a significant association with stunting. At 12 mo, maternal height, birthweight and stunting at 6 mo, while at 24 mo, stunting at 6, 12 and 18 mo were identified as important factors. At 60 mo, no other factors besides previous stunting could be identified. The mean height reached at 60 mo showed a deficit of 6 and 13 cm for the controls and the cases, respectively, compared to the NCHS reference. Twenty-eight percent of the children from the two poor areas who were stunted at 6 mo had improved by 60 mo of age.
The risk factors for stunting varied at different ages, relating more to feeding at early ages and to previous stunting, predominantly at higher ages. The linear growth showed that faltering increased with age when cases and controls were treated separately. Recovery from stunting could also be demonstrated.
采用“巢式”病例对照设计,从1984 - 1987年登记的1236名新生儿的纵向随访队列中识别病例,这些新生儿生活在三个社会经济状况不同的地区。根据美国国家卫生统计中心(NCHS)的参考标准,这些儿童在6、12、24和60月龄时身长<-2标准差(标准差值)。对照组按性别、地区和出生月份进行匹配。采用逻辑回归分析确定各年龄阶段发育迟缓的危险因素。还对这两组儿童的出生后线性生长情况进行了检查,并将体型与NCHS参考标准以及中上层阶级儿童(n = 240)的体型进行了比较。在6月龄时,早产和母乳喂养持续时间与发育迟缓有显著关联。在12月龄时,母亲身高、出生体重以及6月龄时的发育迟缓与之相关,而在24月龄时,6、12和18月龄时的发育迟缓被确定为重要因素。在60月龄时,除了既往发育迟缓外,未发现其他因素。与NCHS参考标准相比,对照组和病例组在60月龄时达到的平均身高分别低6厘米和13厘米。来自两个贫困地区在6月龄时发育迟缓的儿童中,28%到60月龄时有所改善。
发育迟缓的危险因素在不同年龄有所不同,在早期更多与喂养有关,在较高年龄主要与既往发育迟缓有关。线性生长情况表明,分别处理病例组和对照组时,生长发育不良随年龄增加。发育迟缓的恢复情况也得到了证实。