铁破锣苷A - F，从铁破锣中分离得到的六种新的环阿尔廷烷型三萜糖苷。

Beesiosides A-F, six new cycloartane triterpene glycosides from Beesia calthaefolia.

作者信息

Ju Jian-hua, Liu Dong, Lin Geng, Xu Xu-dong, Han Bing, Yang Jun-shan, Tu Guang-zhong, Ma Li-bin

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, People's Republic of China.

出版信息

J Nat Prod. 2002 Jan;65(1):42-7. doi: 10.1021/np010293p.

DOI:10.1021/np010293p

PMID:11809062

Abstract

Six new cycloartane triterpene glycosides (1-6), beesiosides A-F, were isolated from whole plants of Beesia calthaefolia, and their structures were elucidated on the basis of extensive NMR experiments and chemical methods. Beesiosides A-F were assigned as (20S,24R)-epoxy-9,19-cyclolanostane-3beta,16beta,18,25-tetraol-3-O-beta-D-xylopyranoside (1), (20S,24R)-epoxy-9,19-cyclolanostane-3beta,12beta,16beta,18,25-pentaol-3-O-beta-D-xylopyranoside (2), (20S,24R)-epoxy-9,19-cyclolanostane-3beta,12alpha,16beta,18,25-pentaol-3-O-beta-D-xylopyranoside (3), (20S,24R)-16beta-acetoxy-20,24-epoxy-9,19-cyclolanostane-3beta,12alpha,18,25-tetraol-3-O-beta-D-xylopyranoside (4), (20S,24R)-epoxy-9,19-cyclolanostane-3beta,15alpha,16beta,18,25-pentaol-3-O-beta-D-xylopyranoside (5), and (20S,24R)-16beta-acetoxy-20,24-epoxy-9,19-cyclolanostane-3beta,12beta,25-triol-3-O-beta-D-xylopyranoside (6), respectively.

摘要

从铁破锣全草中分离得到6个新的环阿尔廷烷型三萜糖苷（1-6），即铁破锣苷A-F，并通过广泛的核磁共振实验和化学方法对其结构进行了确证。铁破锣苷A-F分别被鉴定为(20S,24R)-环氧-9,19-环羊毛脂烷-3β,16β,18,25-四醇-3-O-β-D-吡喃木糖苷（1）、(20S,24R)-环氧-9,19-环羊毛脂烷-3β,12β,16β,18,25-五醇-3-O-β-D-吡喃木糖苷（2）、(20S,24R)-环氧-9,19-环羊毛脂烷-3β,12α,16β,18,25-五醇-3-O-β-D-吡喃木糖苷（3）、(20S,24R)-16β-乙酰氧基-20,24-环氧-9,19-环羊毛脂烷-3β,12α,18,25-四醇-3-O-β-D-吡喃木糖苷（4）、(20S,24R)-环氧-9,19-环羊毛脂烷-3β,15α,16β,18,25-五醇-3-O-β-D-吡喃木糖苷（5）和(20S,24R)-16β-乙酰氧基-20,24-环氧-9,19-环羊毛脂烷-3β,12β,25-三醇-3-O-β-D-吡喃木糖苷（6）。