一种来自多花多孔菌的脯氨酰内肽酶抑制性苯并呋喃二聚体。
A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex.
作者信息
Song Kyung-Sik, Raskin Ilya
机构信息
Department of Agricultural Chemistry, Kyungpook National University, 1370 Sankyuk-Dong, Taegu 702-701, Korea.
出版信息
J Nat Prod. 2002 Jan;65(1):76-8. doi: 10.1021/np010194b.
PMID:11809072
Abstract
A new benzofuran dimer, 5,6,5',6'-tetrahydroxy[3,3']bibenzofuranyl-2,2'-dicarboxylic acid dimethyl ester (kynapcin-24), was isolated from Polyozellus multiflex and shown to noncompetitively inhibit prolyl endopeptidase (PEP), with an IC(50) value of 1.14 microM. Kynapcin-24 was less inhibitory to other serine proteases such as chymotrypsin, trypsin, and elastase.
摘要
从多褶多孔菌中分离出一种新的苯并呋喃二聚体，5,6,5',6'-四羟基[3,3']联苯并呋喃基-2,2'-二羧酸二甲酯（kynapcin-24），它被证明能非竞争性抑制脯氨酰内肽酶（PEP），IC(50)值为1.14微摩尔。Kynapcin-24对其他丝氨酸蛋白酶如胰凝乳蛋白酶、胰蛋白酶和弹性蛋白酶的抑制作用较小。
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