Chen J, Wen A, Hong D
Department of Obstetrics and Gynecology, Provincial Peoples' Hospital of Guangdong, Guangzhou 510080, China.
Zhonghua Fu Chan Ke Za Zhi. 2000 Feb;35(2):72-4.
To detect the changes of concentrations of serum vascular endothelial growth factor (VEGF) in patients with pregnancy induced hypertension (PIN) as well as to explore the relationship between VEGF and pathogenesis of PIN.
Serum VEGF concentrations in 23 healthy nonpregnant women (nonpregnant group), 30 normal pregnant women (normal pregnancy group) and 37 women with PIH (PIH group) were measured by sandwich enzyme-linked immunoadsorbent assay (ELISA).
Serum concentrations of VEGF were significantly higher in normal pregnancy group (149.39 +/- 27.15) ng/L than those in nonpregnant group (11.98 +/- 3.99) ng/L (P < 0.001), peaking in the second trimester of pregnancy (183.84 +/- 49.02) ng/L and decreasing in the third trimester (118.37 +/- 34.29) ng/L. Serum VEGF concentrations (64.45 +/- 24.33) in PIH group were significantly lower than those in normal late pregnancy group (118.37 +/- 34.29) ng/L (P < 0.01). There was a trend that serum VEGF concentrations in PIH group decreased with the severity of PIH (P < 0.05).
The decrease of VEGF may play and important role in the pathogenic mechanism of PIH.
检测妊娠高血压综合征（PIH）患者血清血管内皮生长因子（VEGF）浓度的变化，探讨VEGF与PIH发病机制之间的关系。
采用双抗体夹心酶联免疫吸附测定法（ELISA）检测23例健康未孕妇女（未孕组）、30例正常孕妇（正常妊娠组）及37例PIH患者（PIH组）血清VEGF浓度。
正常妊娠组血清VEGF浓度（149.39±27.15）ng/L显著高于未孕组（11.98±3.99）ng/L（P<0.001），在妊娠中期达到峰值（183.84±49.02）ng/L，在妊娠晚期降低（118.37±34.29）ng/L。PIH组血清VEGF浓度（64.45±24.33）ng/L显著低于正常妊娠晚期组（118.37±34.29）ng/L（P<0.01）。PIH组血清VEGF浓度有随PIH严重程度降低的趋势（P<0.05）。
VEGF降低可能在PIH发病机制中起重要作用。
