大鼠肝脏胞质部分中嘌呤核苷酸循环进行天冬氨酸脱氨基作用的特征
Characteristics of aspartate deamination by the puring nucleotide cycle in the cytosol fraction of rat liver.
作者信息
Moss K M, McGivan J D
出版信息
Biochem J. 1975 Aug;150(2):275-83. doi: 10.1042/bj1500275.
Abstract
- The component reactions of the puring nucleotide cycle were studied in cytosol extracts of rat liver. 2. AMP deaminase was strongly activated by ATP and analogues of ATP. 3. IMP was converted into ATP by a system requiring the presence of aspartate, GTP and a nucleoside triphosphate-regenerating system. 4. Under appropriate conditions, NH3 was produced from aspartate. 5. From the rates at which these reactions occur it is concluded that the purine nucleotide cycle may have sufficient activity to be a major pathway of amino acid deamination in liver.
摘要
- 在大鼠肝脏的胞质溶胶提取物中研究了嘌呤核苷酸循环的组成反应。2. AMP脱氨酶被ATP及ATP类似物强烈激活。3. IMP通过一个需要天冬氨酸、GTP和核苷三磷酸再生系统存在的体系转化为ATP。4. 在适当条件下，从天冬氨酸产生NH3。5. 根据这些反应发生的速率得出结论，嘌呤核苷酸循环可能具有足够的活性，成为肝脏中氨基酸脱氨的主要途径。
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