Li Xinjun, Hemminki Kari
Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden.
J Clin Epidemiol. 2002 Feb;55(2):111-4. doi: 10.1016/s0895-4356(01)00435-8.
We used the nation-wide Swedish Family-Cancer Database to analyze the risk for bone cancer in offspring by parental cancers and in siblings of bone cancer probands. Additionally, the risk of second cancer following childhood bone cancer was investigated. In offspring, 1,190 bone cancers were diagnosed between years 1958 and 1996. Groups of offspring were compared by calculating standardized incidence ratios (SIRs) for bone cancer. Most bone cancer cases occurred sporadically. Parental breast (SIR 1.7) and prostate (SIR 1.7) cancers were associated with early-onset (<25 years) osteosarcoma in offspring, probably due to Li-Fraumeni syndrome. Giant cell sarcoma was increased by parental breast cancer (SIR 2.9), and early-onset chondrosarcoma by parental kidney cancers (SIR 6.8). Bone cancers conveyed a high risk of second bone and connective tissue cancer.
我们使用瑞典全国家庭癌症数据库，分析了父母患癌情况下子女患骨癌的风险以及骨癌先证者兄弟姐妹患骨癌的风险。此外，还调查了儿童期骨癌后发生二次癌症的风险。在1958年至1996年间，子代中有1190例骨癌被诊断出来。通过计算骨癌的标准化发病比（SIR）对子代群体进行比较。大多数骨癌病例为散发性。父母患乳腺癌（SIR 1.7）和前列腺癌（SIR 1.7）与子代早发性（<25岁）骨肉瘤有关，可能是由于李-佛美尼综合征。父母患乳腺癌会使巨细胞肉瘤风险增加（SIR 2.9），父母患肾癌会使早发性软骨肉瘤风险增加（SIR 6.8）。骨癌会带来较高的二次骨癌和结缔组织癌风险。
