Elder M G
Br J Obstet Gynaecol. 1975 Aug;82(8):674-81. doi: 10.1111/j.1471-0528.1975.tb00705.x.
Uterine action throughout the whole of labour induced by low amniotomy and either oral prostaglandin E2 tablets or intravenous ocytocin was studied in 10 randomly matched pairs of patients. Oral prostaglandin E2 tablets induced fewer contractions per hour, and these contractions were longer and more variable in length than those induced by intravenous oxytocin. There was no difference in basal uterine tone or in the amplitude of contractions. A comparison was made between the outcome of labour induced by low amniotomy and either oral prostaglandin E2 tablets 0-5 mg. hourly in 65 patients, or intravenous ocytocin in 41 patients. This dose of prostaglandin E2 tablets was an inadequate adjunct to low amniotomy in nulliparous patients. Despite this, the induction-delivery interval for the whole prostaglandin group was not significantly greater than that for the oxytocin group. There were no significant differences in fetal heart rate pattern, or in the incidence of gastro-intestinal side-effects between the two groups.
对10对随机匹配的患者进行了研究，观察低位破膜联合口服前列腺素E2片或静脉滴注缩宫素引产时整个产程中的子宫活动情况。口服前列腺素E2片每小时引起的宫缩较少，且这些宫缩比静脉滴注缩宫素引起的宫缩持续时间更长、长度变化更大。基础子宫张力或宫缩幅度没有差异。对65例患者低位破膜联合每小时口服0 - 5毫克前列腺素E2片引产的产程结局与41例患者静脉滴注缩宫素引产的产程结局进行了比较。在未产妇中，该剂量的前列腺素E2片作为低位破膜的辅助用药并不充分。尽管如此，整个前列腺素组的引产至分娩间隔并不显著长于缩宫素组。两组之间胎儿心率模式或胃肠道副作用发生率没有显著差异。
