Roberge Raymond J, Francis Earlie H
Department of Emergency Medicine, St. Francis Medical Center, Pittsburgh, Pennsylvania 15201, USA.
J Emerg Med. 2002 Jan;22(1):67-70. doi: 10.1016/s0736-4679(01)00438-3.
We present a case of a mixed ingestion of valproic acid, gabapentin, mexilitine, and ethanol with central nervous system depression that was reversed by naloxone. This report represents the fourth case demonstrating the antidotal efficacy of naloxone in reversing central nervous system depression associated with acute valproic acid overdose. Increasing clinical experience will more fully elucidate indications for, and optimal dosing of, naloxone in valproic acid toxic states.
我们报告一例同时摄入丙戊酸、加巴喷丁、美西律和乙醇导致中枢神经系统抑制，后被纳洛酮逆转的病例。本报告是第四例证明纳洛酮对逆转与急性丙戊酸过量相关的中枢神经系统抑制具有解毒功效的病例。越来越多的临床经验将更全面地阐明纳洛酮在丙戊酸中毒状态下的适应证及最佳剂量。
