γ-变形菌纲中FUR调控子的比较分析
Comparative analysis of FUR regulons in gamma-proteobacteria.
作者信息
Panina E M, Mironov A A, Gelfand M S
机构信息
State Scientific Center GosNIIGenetika, 1st Dorozhny prospect, Moscow 113545, Russia.
出版信息
Nucleic Acids Res. 2001 Dec 15;29(24):5195-206. doi: 10.1093/nar/29.24.5195.
Abstract
Iron is an essential element for the survival and pathogenesis of bacteria. The strict control of iron homeostasis is mediated by the FUR repressor, which is highly conserved among various bacterial species. Here we apply the comparative genomics approach to analyze candidate Fur-binding sites in the genomes of Escherichia coli (K12 and O157:H7), Salmonella typhi, Yersinia pestis and Vibrio cholerae. We describe a number of new loci encoding siderophore biosynthesis and transport proteins. A new regulator of iron-acquisition systems was found in S.typhi. We predict FUR regulation for several virulence systems. We also predict FUR regulation for the chemotaxis system of V.cholerae that is probably involved in the process of pathogenesis.
摘要
铁是细菌生存和致病的必需元素。铁稳态的严格控制由FUR阻遏物介导，该阻遏物在各种细菌物种中高度保守。在这里，我们应用比较基因组学方法分析大肠杆菌（K12和O157:H7）、伤寒沙门氏菌、鼠疫耶尔森菌和霍乱弧菌基因组中的候选Fur结合位点。我们描述了一些编码铁载体生物合成和转运蛋白的新基因座。在伤寒沙门氏菌中发现了一种新的铁获取系统调节因子。我们预测了几种毒力系统的FUR调控。我们还预测了霍乱弧菌趋化系统的FUR调控，该系统可能参与致病过程。
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