Suzuki H, Kuriyama H
Jpn J Physiol. 1975;25(3):345-56. doi: 10.2170/jjphysiol.25.345.
Effects of prostaglandin E2 (PGE2) and oxytocin on the membrane activity of pregnant mouse myometrium were investigated with the microelectrode method. Sensitivity of the myometrium to oxytocin increased only during the last stage of gestation, however sensitivity to PGE2 gradually increased beginning at the middle stage of gestation. Prolonged treatment with PGE2 but not with oxytocin produced desensitization of the myometrium. When the membrane potential was electrically displaced to the resting level after the membrane had been markedly depolarized by either PGE2 or oxytocin, spike activity was restored. However with PGE2 there was continuous spike generation and with oxytocin periodic burst discharges with silent periods. In Ca-free Locke solution, PGE2 and oxytocin still produced depolarization of the membrane, however, oxytocin produced larger depolarization. The different responses of the membrane to PGE2 and oxytocin are discussed in relation to the roles of Ca ion and to the ovarian and placental hormones during gestation.
采用微电极法研究了前列腺素E2（PGE2）和催产素对妊娠小鼠子宫肌层膜活性的影响。子宫肌层对催产素的敏感性仅在妊娠后期增加，而对PGE2的敏感性从妊娠中期开始逐渐增加。PGE2而非催产素的长期处理会导致子宫肌层脱敏。当膜被PGE2或催产素显著去极化后，膜电位电位移至静息水平时，峰电位活动得以恢复。然而，PGE2会持续产生峰电位，而催产素则会产生伴有静息期的周期性爆发性放电。在无钙的洛克溶液中，PGE2和催产素仍会使膜去极化，不过，催产素产生的去极化幅度更大。结合钙离子的作用以及妊娠期间卵巢和胎盘激素，讨论了膜对PGE2和催产素的不同反应。
