Brand Nico, Geenen Rinie, Oudenhoven Milo, Lindenborn Bastiaan, van der Ree Annette, Cohen-Kettenis Peggy, Buitelaar Jan K
Department of Health Psychology, Utrecht University, The Netherlands.
J Pediatr Psychol. 2002 Mar;27(2):203-8. doi: 10.1093/jpepsy/27.2.203.
To examine whether patients with Tourette's syndrome (TS) with and without comorbid attention deficit and hyperactivity disorder (ADHD) differ in cognitive functioning and whether a higher level of cognitive functioning is associated with severity of TS symptoms and psychosocial functioning.
Cognitive functioning, symptom severity, and psychosocial functioning were examined in 40 patients (33 boys, 7 girls; age range 6-18 years) with TS, of whom 17 had the comorbid diagnosis of ADHD.
Patients with a comorbid ADHD diagnosis evidenced poorer performance than those with TS alone with respect to severity of TS symptoms, psychosocial functioning, verbal and performance intelligence, and word fluency, but not on tests of cognitive flexibility. Psychosocial functioning was predicted by symptom severity, but not by intelligence or fluency.
Results confirm prior findings that comorbid ADHD is associated with more TS symptoms and worse psychosocial and cognitive functioning, and motivate whether cognitive flexibility plays a role in moderating the deleterious psychosocial effects of Tourette's syndrome and ADHD.
研究患有和未患有共病注意缺陷多动障碍(ADHD)的抽动秽语综合征(TS)患者在认知功能上是否存在差异,以及较高水平的认知功能是否与TS症状的严重程度和心理社会功能相关。
对40例TS患者(33名男孩,7名女孩;年龄范围6 - 18岁)进行认知功能、症状严重程度和心理社会功能检查,其中17例患有共病ADHD。
共病ADHD的患者在TS症状严重程度、心理社会功能、言语和操作智力以及词汇流畅性方面的表现比单纯患有TS的患者差,但在认知灵活性测试中并非如此。心理社会功能由症状严重程度预测,而非由智力或流畅性预测。
结果证实了先前的研究发现,即共病ADHD与更多的TS症状以及更差的心理社会和认知功能相关,并引发了关于认知灵活性是否在调节抽动秽语综合征和ADHD的有害心理社会影响中起作用的思考。