小鼠毛囊间表皮和毛囊中鸟氨酸脱羧酶活性与DNA合成的关系。

Ornithine decarboxylase activity in relation to DNA synthesis in mouse interfollicular epidermis and hair follicles.

作者信息

Probst E, Krebs A

出版信息

Biochim Biophys Acta. 1975 Oct 1;407(2):147-57. doi: 10.1016/0005-2787(75)90281-6.

Abstract

The relationship between ornithine decarboxylase (L-ornithine carboxylyase, EC 4.1.1.17) activity and DNA synthetic activity was studied in mouse epidermis. Interfollicular epidermis and hair follicles were investigated separately. It was found that, in hair follicles, the variations of DNA replicative activity, which are reflected in the cyclic growth of hair, are paralleled by corresponding changes in ornithine decarboxylase activity. In both interfollicular epidermis and hair follicles, stimulation of DNA synthetic activity by plucking of hair induced a rapid and marked increase in ornithine decarboxylase activity. The relationship of steady-state and induced ornithine decarboxylase activity to DNA synthetic activity was compared in hair follicles and interfollicular epidermis. A correlation between the activity of this enzyme and DNA replication was found thereby in each of these tissues.

摘要

在小鼠表皮中研究了鸟氨酸脱羧酶（L-鸟氨酸羧化酶，EC 4.1.1.17）活性与DNA合成活性之间的关系。分别对毛囊间表皮和毛囊进行了研究。结果发现，在毛囊中，DNA复制活性的变化反映在毛发的周期性生长中，与鸟氨酸脱羧酶活性的相应变化平行。在毛囊间表皮和毛囊中，拔毛刺激DNA合成活性均诱导鸟氨酸脱羧酶活性迅速且显著增加。比较了毛囊和毛囊间表皮中稳态和诱导的鸟氨酸脱羧酶活性与DNA合成活性的关系。由此发现，在这些组织中的每一个中，该酶的活性与DNA复制之间都存在相关性。