线粒体毒素3-硝基丙酸会加重利血平诱导的大鼠口腔运动障碍。
The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats.
作者信息
Calvente Patricia R V, Araujo Carlos C S, Bergamo Marcelo, Abilio Vanessa C, D'Almeida Vânia, Ribeiro Rosana De A, Frussa Filho Roberto
机构信息
Departamento de Farmacologia, São Paulo, SP, Brazil.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):401-5. doi: 10.1016/s0278-5846(01)00255-x.
The effects of a previous long-term administration of the mitochondrial toxin 3-nitropropionic acid were studied on an animal model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine. 3-Nitropropionic acid (10 or 15 mg/kg i.p., every other day for 17 days) potentiated the increase in tongue-protrusion frequency induced by reserpine (1 mg/kg, s.c., every other day for 3 days) but did not modify reserpine-induced increase in immobility duration and decrease in locomotion frequency. These results support the notion that neurotoxic events are associated with the development of tardive dyskinesia.
研究了先前长期给予线粒体毒素3-硝基丙酸对迟发性运动障碍动物模型的影响，即对反复给予利血平的大鼠自发性伸舌频率的影响。3-硝基丙酸（10或15毫克/千克腹腔注射，每隔一天注射一次，共17天）增强了利血平（1毫克/千克皮下注射，每隔一天注射一次，共3天）诱导的伸舌频率增加，但未改变利血平诱导的不动时间增加和运动频率降低。这些结果支持了神经毒性事件与迟发性运动障碍的发生有关的观点。
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