Beck W, Wuttke W
J Endocrinol. 1979 Nov;83(2):131-9. doi: 10.1677/joe.0.0830131.
Six male rhesus monkeys were kept under rigidly controlled conditions for 1-2 years. During August of the first year a thyrotrophin releasing hormone (TRH) test was performed on each of the monkeys by giving 10 microgram TRH as a bolus injection. Significantly increased serum prolactin levels occurred 15 min after the injection. After a training period of 2 months, during which blood samples were collected every other day by puncture of the saphenous vein, blood was collected three times a week for 14 months. Serum levels of prolactin, LH, FSH and testosterone were measured by radioimmunoassay. Mean serum prolactin levels increased significantly during June, July and August in all six animals. Peak levels were observed in August and September and then levels declined gradually to reach a minimum in April and May. Mean serum testosterone levels closely paralleled the annual pattern of prolactin. Mean serum LH levels significantly decreased during the time when mean serum prolactin and testosterone levels were increasing and they increased again at the time of decreasing mean prolactin levels, i.e. mean serum LH and prolactin were negatively correlated. In individual monkeys, however, a rigid negative correlation between serum prolactin and LH could not be demonstrated. Mean serum FSH levels did not change significantly.
六只雄性恒河猴在严格控制的条件下饲养1至2年。在第一年的八月，对每只猴子进行促甲状腺激素释放激素（TRH）测试，通过静脉推注给予10微克TRH。注射后15分钟血清催乳素水平显著升高。经过2个月的训练期，在此期间每隔一天通过穿刺隐静脉采集血样，之后每周采集三次血样，持续14个月。通过放射免疫分析法测定血清催乳素、促黄体生成素（LH）、促卵泡生成素（FSH）和睾酮的水平。所有六只动物的血清催乳素平均水平在六月、七月和八月显著升高。八月和九月观察到峰值水平，然后水平逐渐下降，在四月和五月达到最低值。血清睾酮平均水平与催乳素的年度模式密切平行。血清LH平均水平在血清催乳素和睾酮平均水平升高时显著下降，而在血清催乳素水平下降时再次升高，即血清LH和催乳素呈负相关。然而，在个体猴子中，血清催乳素和LH之间的严格负相关无法得到证实。血清FSH平均水平没有显著变化。
