Davis Cindy D, Zeng Huawei, Finley John W
U. S. Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202-9034, USA.
J Nutr. 2002 Feb;132(2):307-9. doi: 10.1093/jn/132.2.307.
Multiple intestinal neoplasia (Min) mice are a good model for the investigation of the effects of dietary alterations in a genetic model for intestinal cancer. Previous studies have shown that selenium-enriched broccoli is protective against chemically induced colon cancer susceptibility. This study investigated whether selenium-enriched broccoli would be protective against intestinal cancer susceptibility in Min mice. Five-week-old heterozygotic male Min mice were fed an AIN-93-based diet containing either low-selenium broccoli or an equivalent amount of high-selenium broccoli for 10 wk. Mice fed the selenium-enriched broccoli had fewer (P < 0.02) small intestinal (46.4 +/- 3.7 vs. 65.6 +/- 6.1) and large intestinal (0.43 +/- 0.17 vs. 1.93 +/- 0.27) tumors than those fed an equivalent amount of unenriched broccoli. Min mice fed the selenium-enriched broccoli had small but significant (P < 0.0001) increases in plasma and liver selenium concentrations and red blood cell glutathione peroxidase activity. These results extend previous observations that selenium-enriched broccoli is protective against chemically induced mammary and colon cancer in rats.
多发性肠道肿瘤（Min）小鼠是研究饮食改变对肠道癌遗传模型影响的良好模型。先前的研究表明，富硒西兰花对化学诱导的结肠癌易感性具有保护作用。本研究调查了富硒西兰花是否对Min小鼠的肠道癌易感性具有保护作用。将5周龄的杂合子雄性Min小鼠喂食基于AIN-93的饮食，其中含有低硒西兰花或等量的高硒西兰花，持续10周。喂食富硒西兰花的小鼠小肠（46.4±3.7对65.6±6.1）和大肠（0.43±0.17对1.93±0.27）肿瘤比喂食等量未富集西兰花的小鼠少（P<0.02）。喂食富硒西兰花的Min小鼠血浆和肝脏硒浓度以及红细胞谷胱甘肽过氧化物酶活性有小幅但显著（P<0.0001）的增加。这些结果扩展了先前的观察结果，即富硒西兰花对大鼠化学诱导的乳腺癌和结肠癌具有保护作用。
