Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV, 26506, USA.
Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
Plant Foods Hum Nutr. 2019 Dec;74(4):449-460. doi: 10.1007/s11130-019-00769-z.
Selenium supplementation in humans has been suggested for the prevention of chronic diseases including cardiovascular disease, cancer, and neurodegenerative diseases. Selenium biofortification of plants has been explored as a method for increasing selenium content of food and dietary selenium intake in humans. However, the effects of selenium biofortification on other dietary nutrients is often a secondary discussion. These effects are especially important to explore considering selenium-biofortified foods contain many other nutrients important to human health, such as other minerals and antioxidant compounds, which can make these foods superior to selenium supplementation alone. Investigation of selenium biofortification's effect on these nutrients is necessary for a comprehensive human nutrition perspective on biofortification strategies. This review considers the effects of selenium biofortification on selenium content, other minerals, and antioxidant compounds as they pertain to human health in order to suggest optimal strategies for biofortification. Pre-clinical and clinical studies assessing the effects of consumption of selenium biofortified foods are also discussed.
已有人提议通过补充硒来预防慢性疾病，包括心血管疾病、癌症和神经退行性疾病。植物的硒生物强化已被探索作为一种增加食物硒含量和人类膳食硒摄入量的方法。然而，硒生物强化对其他膳食营养素的影响通常是次要的讨论。考虑到硒生物强化食品含有许多其他对人类健康很重要的营养物质，如其他矿物质和抗氧化化合物，因此探索这些影响尤为重要，这些物质可以使这些食品优于单独补充硒。从全面的人类营养角度来看，生物强化策略需要研究硒生物强化对这些营养素的影响。本综述考虑了硒生物强化对硒含量、其他矿物质和抗氧化化合物的影响，因为它们与人类健康有关，以提出生物强化的最佳策略。还讨论了评估食用硒生物强化食品的影响的临床前和临床研究。
