Regulation of naïve and memory T-cell homeostasis.
作者信息
Surh Charles D, Sprent Jonathan
机构信息
Department of Immunology, IMM26, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Microbes Infect. 2002 Jan;4(1):51-6. doi: 10.1016/s1286-4579(01)01509-x.
Abstract
Recent work has confirmed the existence of homeostatic mechanisms that regulate the overall size and composition of the mature T-cell pool. Homeostatic mechanisms not only control total T-cell numbers but appear to act differently on naïve vs. memory cells. The roles of self-MHC/peptide ligands and certain cytokines in T-cell homeostasis are discussed.
摘要
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