Surh Charles D, Sprent Jonathan
The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Immunity. 2008 Dec 19;29(6):848-62. doi: 10.1016/j.immuni.2008.11.002.
The peripheral mature T cell pool is regulated by complex homeostatic mechanisms. Naive T cells are maintained by interleukin-7 (IL-7) and T cell receptor (TCR) signaling from contact with major histocompatibility complex (MHC), which sustain expression of antiapoptotic molecules and allow the cells to survive in interphase. Competition for these ligands declines when T cell numbers are reduced and causes residual naive T cells to proliferate and differentiate into memory-like cells. This memory cell population is thus heterogeneous and comprised of cells derived from responses to both foreign and self-antigens. Typical memory cells are kept alive and induced to divide intermittently by a mixture of IL-7 and IL-15. This review highlights recent advances in how naive and memory T cell homeostasis is regulated.
外周成熟T细胞库受复杂的稳态机制调控。初始T细胞通过白细胞介素-7（IL-7）和与主要组织相容性复合体（MHC）接触产生的T细胞受体（TCR）信号得以维持，这些信号维持抗凋亡分子的表达并使细胞在间期存活。当T细胞数量减少时，对这些配体的竞争减弱，导致残余的初始T细胞增殖并分化为记忆样细胞。因此，这个记忆细胞群体是异质性的，由对外源和自身抗原应答产生的细胞组成。典型的记忆细胞通过IL-7和IL-15的混合物维持存活并被诱导间歇性分裂。本综述重点介绍了初始和记忆T细胞稳态调控方面的最新进展。
