Lin C Y, Smith S, Abraham S
Cancer Res. 1975 Nov;35(11 Pt 1):3094-9.
Fatty acid synthetase was isolated from transplantable mammary adenocarcinomas carried by C3H mice. Comparison of physicochemical and immunological properties of this enzyme with those of the fatty acid synthetase isolated from normal glands of lactating C3H mice indicates that the enzymes are similar in all respects. The products of the purified fatty acid synthetase from normal and neoplastic tissues were the same, mainly long-chain fatty acids. The normal gland was found to contain 30 times more enzymes per g tissue than did the neoplasm; this may account in part for the relatively low rat of fatty acid synthetase found previously in this neoplasm.
脂肪酸合成酶是从C3H小鼠携带的可移植性乳腺腺癌中分离出来的。将这种酶的物理化学性质和免疫学性质与从泌乳C3H小鼠的正常腺体中分离出的脂肪酸合成酶进行比较，结果表明这两种酶在各方面都相似。从正常组织和肿瘤组织中纯化得到的脂肪酸合成酶的产物是相同的，主要是长链脂肪酸。研究发现，正常腺体每克组织中所含的酶比肿瘤组织多30倍；这可能部分解释了此前在该肿瘤中发现的脂肪酸合成酶活性相对较低的原因。
