Molassiotis A
Department of Nursing, Chinese University of Hong Kong.
Eur J Cancer Care (Engl). 2000 Dec;9(4):230-4. doi: 10.1046/j.1365-2354.2000.00220.x.
The aim of this pilot study was to assess the effectiveness of using progressive muscle relaxation training (PMRT) in the management of chemotherapy-related nausea and vomiting in Chinese breast cancer patients receiving doxorubicin and cyclophosphamide as well as feasibility issues for a larger study. Eight patients were randomly assigned to receive either oral anti-emetics as per hospital protocol (maxolon) or adjuvant PMRT. Both groups, however, received intravenous anti-emetics half an hour before the chemotherapy administration. PMRT was given by a trained nurse once a day for 5 days. A repeated measures design was used. Nausea and vomiting were assessed with the Morrow Nausea and Vomiting Scale. Results indicated that the duration and intensity of nausea were lower in the experimental group, although the former was at a borderline level of significance. The duration and intensity of vomiting were also lower in the experimental group. Delayed nausea and vomiting was observed in both groups. Despite the small sample size, the study showed that PMRT is an effective adjuvant method to decrease nausea and vomiting in chemotherapy patients. This has implications for nursing practice, as it is a low-cost and easy-to-leam technique that can be incorporated in the care planning of patients receiving chemotherapy.
本初步研究的目的是评估在中国接受阿霉素和环磷酰胺治疗的乳腺癌患者中,采用渐进性肌肉放松训练(PMRT)来管理化疗相关恶心和呕吐的有效性,以及进行更大规模研究的可行性问题。8名患者被随机分配,一组按照医院方案接受口服止吐药(胃复安),另一组接受辅助性PMRT。然而,两组在化疗给药前半小时均接受静脉注射止吐药。PMRT由一名经过培训的护士每天进行一次,共进行5天。采用重复测量设计。使用Morrow恶心呕吐量表评估恶心和呕吐情况。结果表明,尽管实验组恶心的持续时间仅处于临界显著水平,但实验组恶心的持续时间和强度较低。实验组呕吐的持续时间和强度也较低。两组均观察到延迟性恶心和呕吐。尽管样本量较小,但该研究表明PMRT是一种有效的辅助方法,可减少化疗患者的恶心和呕吐。这对护理实践具有启示意义,因为它是一种低成本且易于学习的技术,可纳入接受化疗患者的护理计划中。