Friedman G D, Klatsky A L, Siegelaub A B
Circulation. 1975 Dec;52(6 Suppl):III164-9.
A search was made for predictors of sudden cardiac death (SCD) among 197 men, age 40 to 79, who had multiphasic health checkups and experienced SCD 2 days to 5 1/2 years later (mean 18.1 months). Two age-sex-race-matched control groups, one matched and one unmatched for standard coronary risk factors, have been compared to the cases. In this ambulatory population, SCD occurred largely in persons with prior diagnosed heart disease. Standard coronary risk factors were confirmed as predictors of SCD. Predictors among other laboratory and quantitative tests include chylous serum, uric acid, hemoglobin, leukocyte count, pulse rate, diminished lung volumes, and hearing loss. Some of these had predictive value independent of standard risk factors. Pain tolerance was not related to SCD or to death in, versus out of hospital. Most of these predictors were not related to terminal symptom duration; this suggests a relationship more to the underlying atherosclerotic process than to the terminal fatal mechanism.
在197名年龄在40至79岁之间的男性中进行了一项研究，这些男性接受了多阶段健康检查，并在2天至5年半后（平均18.1个月）发生了心源性猝死（SCD）。将两个年龄、性别、种族匹配的对照组与病例组进行了比较，其中一个对照组在标准冠状动脉危险因素方面匹配，另一个不匹配。在这个非卧床人群中，SCD主要发生在先前被诊断患有心脏病的人身上。标准冠状动脉危险因素被确认为SCD的预测指标。其他实验室检查和定量测试中的预测指标包括乳糜血清、尿酸、血红蛋白、白细胞计数、脉搏率、肺容量减小和听力丧失。其中一些指标具有独立于标准危险因素的预测价值。疼痛耐受性与SCD或院外死亡无关。这些预测指标大多与终末期症状持续时间无关；这表明其与潜在的动脉粥样硬化过程的关系比与终末期致命机制的关系更大。
