Lu X, Mao L
Department of Thoracic Surgery, Huashan Hospital, Shanghai Medical University, Shanghai 200040.
Zhonghua Wai Ke Za Zhi. 1999 Mar;37(3):159-61.
To evaluate the long-term outcome and relevant factors of thymectomy for myasthenia gravis (MG) by analyzing patients data.
114 patients with MG operated between May 1990 and 1997 were reviewed. The results of operation were classified in to 4 grades: remission, improvement (efficiency includes remission and improvement), no change, and deterioration. The relativity between the long-term outcome and the factors of age, sex, the serum titer of AchR antibodies, duration of disease, pathological classification of thymus, modified osserman classification, and follow-up period was analyzed by logistic and chi(2) test.
There were 47 man and 67 women aged from 4 to 72 years. Follow-up ranged from 10 to 82 months (mean 42, 8 months). The remission rate was 27.2% and the effective rate 67.5%. No patient died in the hospital, and the late-death rate was 7.0% (8 cases).
Long follow-up (over 5 years) is necessary for evaluating the results of the treatment. There is no correlation between the outcome sex, and the serum titer of AchR antibodies. Associated diseases show no influence on the outcome of thymectomy.
通过分析患者数据评估重症肌无力（MG）胸腺切除术的长期疗效及相关因素。
回顾1990年5月至1997年期间接受手术的114例MG患者。手术结果分为4级：缓解、改善（有效包括缓解和改善）、无变化和恶化。通过逻辑回归和卡方检验分析长期疗效与年龄、性别、乙酰胆碱受体（AchR）抗体血清滴度、病程、胸腺病理分类、改良奥斯曼分类及随访时间等因素之间的相关性。
患者年龄4至72岁，男性47例，女性67例。随访时间为10至82个月（平均42.8个月）。缓解率为27.2%，有效率为67.5%。无患者在医院死亡，晚期死亡率为7.0%（8例）。
评估治疗结果需要进行长期随访（超过5年）。疗效与性别、AchR抗体血清滴度无关。伴发疾病对胸腺切除术的疗效无影响。
