血液透析期间肝素治疗导致淀粉碘法测定的淀粉酶值出现假性升高。

False rise of starch-iodine determined amylase values caused by heparin treatment during haemodialysis.

作者信息

Pasternack A, Stenman U H

出版信息

Clin Chim Acta. 1975 Dec 1;65(2):213-21. doi: 10.1016/0009-8981(75)90110-2.

Abstract

A false rise in the levels of serum amylase as determined by a starch-iodine method was observed in patients undergoing haemodialysis and after treatment with heparin. In in vitro experiments, neither dialysis of serum nor addition of heparin produced a corresponding increase. The results showed that lipoproteins, altered by heparin-induced lipoprotein lipase, may have a considerable influence by interacting with starch and thereby partly preventing the formation of starch-iodine complexes. Amyloclastic methods that employ the starch-iodine reaction for determining amylase are therefore not to be used on patients treated with heparin.

摘要

在接受血液透析的患者以及使用肝素治疗后的患者中，观察到通过淀粉 - 碘法测定的血清淀粉酶水平出现假性升高。在体外实验中，血清透析和添加肝素均未产生相应的升高。结果表明，由肝素诱导的脂蛋白脂肪酶改变的脂蛋白，可能通过与淀粉相互作用而产生相当大的影响，从而部分地阻止淀粉 - 碘复合物的形成。因此，采用淀粉 - 碘反应来测定淀粉酶的淀粉分解方法不适用于接受肝素治疗的患者。