Jaiswal A K
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 2001 Sep;39(9):853-7.
Environmental deprivation (ED) induced a significant increase in open-field ambulation, rears, self-groomings, faecal pellets and decrease in activity in centre in Charles Foster albino rats of 30, 45 and 60 days age groups. In elevated plus maze, significant attenuation of open arm time/entries and augmentation of enclosed arm time/entries were noted in ED rats of all the three age groups. Similarly ED rats also showed significant decrease in time spent on open arms, entries, head dips and stretched attend postures in comparison to age matched rats reared under normal environmental conditions. The results indicate that imposition of environmental deprivation in rats' life consistently resulted in significant anxiogenic behaviour on all the tests. However, the anxiogenic effect of ED was less marked when it was imposed at 60th day of life in rats.
环境剥夺（ED）导致30、45和60日龄组的查尔斯·福斯特白化大鼠在旷场实验中的走动、直立、自我梳理、粪便颗粒显著增加，而在中央区域的活动减少。在高架十字迷宫实验中，所有三个年龄组的ED大鼠均出现开放臂时间/进入次数显著减少，封闭臂时间/进入次数增加。同样，与在正常环境条件下饲养的年龄匹配大鼠相比，ED大鼠在开放臂上花费的时间、进入次数、头部下垂和伸展姿势也显著减少。结果表明，在大鼠生命中施加环境剥夺在所有测试中均持续导致显著的焦虑行为。然而，当在大鼠生命的第60天施加ED时，其焦虑效应不太明显。
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