Yuan X, Shao Y, Cui X, Zheng C
Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
Zhonghua Wai Ke Za Zhi. 2000 Jul;38(7):499-501.
To study the clinicopathological characteristics of T(2) gastric cancer and its postoperative recurrence.
124 T(2) gastric cancer patients were divided into two groups: 42 patients with postoperative recurrence (Group 1) and 82 patients without recurrence (Group 2).
The recurrence rate of local tumor was significantly lower in Group 1 (26.2%) than in Group 2 (45.1%). Deep invasion was highly different between the two groups. Circular muscle tumors were seen in Group 1 (4.8%) and in Group 2 (30.5%), whereas sub-serosa tumors were seen in Group 1 (61.8%) and in Group 2 (25.6%). The rate of lymph node metastasis was significantly higher in Group 1 (88.1%) than in Group 2 (57.3%). The mean number of positive nodes was (7.02 +/- 6.50) in Group 1 and (2.16 +/- 2.04) in Group 2(P < 0.01). Local recurrence rate and distant metastasis rate in Group 1 were 54.8% and 46.2% respectively. The median survival was 26.5 months in Group 1 and 57.0 months in Group 2 (P < 0.01). The 1-, 3-, 5-year survival rate in Group 1 and Group 2 were 61.4% vs 97.6%, 18.7% vs 95.9%, and 8.3% vs 95.9%, respectively.
Poor prognosis is seen in T(2) gastric cancer patients with postoperative recurrence. Extended gastrectomy and multi-therapy are necessary for the patients with the risk factors so as to decrease local recurrence.
研究T（2）期胃癌的临床病理特征及其术后复发情况。
将124例T（2）期胃癌患者分为两组：42例术后复发患者（第1组）和82例未复发患者（第2组）。
第1组局部肿瘤复发率（26.2%）显著低于第2组（45.1%）。两组在深层浸润方面差异显著。第1组可见环形肌层肿瘤（4.8%），第2组可见（30.5%）；而第1组可见浆膜下肿瘤（61.8%），第2组可见（25.6%）。第1组淋巴结转移率（88.1%）显著高于第2组（57.3%）。第1组阳性淋巴结平均数为（7.02±6.50），第2组为（2.16±2.04）（P<0.01）。第1组局部复发率和远处转移率分别为54.8%和46.2%。第1组中位生存期为26.5个月，第2组为57.0个月（P<0.01）。第1组和第2组的1年、3年、5年生存率分别为61.4%对97.6%、18.7%对95.9%、8.3%对95.9%。
术后复发的T（2）期胃癌患者预后较差。对于有危险因素的患者，扩大根治性胃切除术和综合治疗是必要的，以降低局部复发率。
