生物人工肝——当前技术水平

A bioartificial liver--state of the art.

作者信息

Strain Alastair J, Neuberger James M

机构信息

Schools of Biosciences and Medicine, University of Birmingham, and Liver and Hepatobiliary Unit, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK.

出版信息

Science. 2002 Feb 8;295(5557):1005-9. doi: 10.1126/science.1068660.

DOI:10.1126/science.1068660

PMID:11834813

Abstract

End-stage liver disease is treated by liver transplantation, but donor organ shortages remain a serious problem. This has prompted the design of bioartificial liver devices to "bridge" patients until they either recover or receive a liver transplant. In these devices, patient plasma is circulated extracorporeally through a bioreactor that houses liver cells (hepatocytes) sandwiched between artificial plates or capillaries.

摘要

终末期肝病通过肝移植进行治疗，但供体器官短缺仍是一个严重问题。这促使人们设计生物人工肝装置，以便在患者康复或接受肝移植之前“过渡”使用。在这些装置中，患者血浆通过体外循环，流经一个生物反应器，该反应器中夹在人工板或毛细血管之间的是肝细胞。