Liu Qiji, Gong Yaoqin, Chen Bingxi, Guo Chenhong, Li Jiangxia, Guo Yishou
Department of Medical Genetics, School of Medicine, Shandong University, Jinan, Shandong, 250012 P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Feb;19(1):22-5.
To determine the linkage between Smith-Fineman-Myers syndrome (SFMS) and X-linked nuclear protein(XNP) locus.
Polymerase chain reaction and denaturing polyacrylamide gel electrophoresis were used to genotype two polymorphic short tandem repeats within XNP gene.
One of the two short tandem repeats was informative in SFMS family from Shandong, China. Recombination between SFMS locus and XNP gene was observed in the SFMS family.
XNP gene is not associated with the disease in the SFMS family from Shandong, China. SFMS exhibits locus heterogeneity at molecular level.
