Selvadurai H C, Blimkie C J, Meyers N, Mellis C M, Cooper P J, Van Asperen P P
Children's Chest Research Centre and Department of Respiratory Medicine, Royal Alexandra Hospital for Children, New South Wales, Australia.
Pediatr Pulmonol. 2002 Mar;33(3):194-200. doi: 10.1002/ppul.10015.
The aim of this study was to compare aerobic and resistance training in children with cystic fibrosis (CF) admitted to hospital with an intercurrent pulmonary infection with a control group. The subjects were randomized into three groups on the first day of admission. The fat-free mass (FFM) was calculated, using the skin fold thickness from four sites (biceps, triceps, subscapular, and iliac crest). Pulmonary function tests were performed within 36 hr of admission and repeated on discharge from the hospital, and again at 1 month after discharge. All subjects performed an incremental treadmill exercise test, using a modified Bruce protocol. Lower limb strength was measured using a Cybex dynamometer. An assessment of quality of life was made using the Quality of Well Being Scale, as previously reported. Activity levels were measured using a 7-day activity diary, and subjects also wore an accelerometer on their hips. There were no significant differences between the three groups in terms of disease severity, and length of stay in hospital. Subjects in all three groups received intravenous antibiotics and nutritional supplementation as determined by the physician. Children randomized to the aerobic training group participated in aerobic activities for five sessions, each of 30-min duration, a week. The children randomized to the resistance training group exercised both upper and lower limbs against a graded resistance machine. Subjects in the control group received standard chest physiotherapy. Our study demonstrated that children who received aerobic training had significantly better peak aerobic capacity, activity levels, and quality of life than children who received the resistance training program. Children who received resistance training had better weight gain (total mass, as well as fat-free mass), lung function, and leg strength than children who received aerobic training. A combination of aerobic and resistance training may be the best training program, and future studies to assess optimal training programs for CF patients are indicated.
本研究的目的是比较因并发肺部感染而住院的囊性纤维化（CF）患儿进行有氧训练和抗阻训练的效果，并与对照组进行对比。受试者在入院第一天被随机分为三组。使用四个部位（肱二头肌、肱三头肌、肩胛下和髂嵴）的皮褶厚度计算去脂体重（FFM）。入院36小时内进行肺功能测试，并在出院时重复测试，出院后1个月再次测试。所有受试者均使用改良的布鲁斯方案进行递增式跑步机运动测试。使用Cybex测力计测量下肢力量。如先前报道，使用幸福质量量表对生活质量进行评估。使用7天活动日记测量活动水平，受试者还在臀部佩戴加速度计。三组在疾病严重程度和住院时间方面无显著差异。所有三组受试者均接受医生确定的静脉抗生素治疗和营养补充。随机分配到有氧训练组的儿童每周参加五次有氧活动，每次持续30分钟。随机分配到抗阻训练组的儿童对上肢和下肢进行抗阻分级器械训练。对照组受试者接受标准的胸部物理治疗。我们的研究表明，接受有氧训练的儿童在峰值有氧能力、活动水平和生活质量方面明显优于接受抗阻训练计划的儿童。接受抗阻训练的儿童在体重增加（总体重以及去脂体重）、肺功能和腿部力量方面优于接受有氧训练的儿童。有氧训练和抗阻训练相结合可能是最佳训练方案，因此有必要开展未来研究以评估CF患者的最佳训练方案。
