Id蛋白在淋巴细胞发育中的调控与功能。

The regulation and function of the Id proteins in lymphocyte development.

作者信息

Rivera R, Murre C

机构信息

Division of Biology, 0366, University of California at San Diego, La Jolla, CA 92093, USA.

出版信息

Oncogene. 2001 Dec 20;20(58):8308-16. doi: 10.1038/sj.onc.1205091.

DOI:10.1038/sj.onc.1205091

PMID:11840323

Abstract

Helix-loop-helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development.

摘要

螺旋-环-螺旋（HLH）蛋白是淋巴细胞发育和功能的关键因子。一类HLH蛋白，即E蛋白，调控淋巴细胞成熟、存活、增殖和分化的多个方面。E蛋白受到另一类称为Id蛋白的HLH蛋白的负调控。Id蛋白通过抑制E蛋白结合DNA的能力，作为E蛋白的显性负性抑制剂发挥作用。在此，我们讨论Id蛋白在淋巴细胞发育中的功能和调控。