E蛋白和Id蛋白在淋巴细胞发育中的作用。

The function of E- and Id proteins in lymphocyte development.

作者信息

Engel I, Murre C

机构信息

Division of Biology, University of California, San Diego, La Jolla 92093, USA.

出版信息

Nat Rev Immunol. 2001 Dec;1(3):193-9. doi: 10.1038/35105060.

DOI:10.1038/35105060

PMID:11905828

Abstract

Helix-loop-helix proteins are essential factors for lymphocyte development and function. In particular, E-proteins are crucial for commitment of lymphoid progenitors to the B- and T-cell lineages. E-proteins are negatively regulated by the Id class of helix-loop-helix proteins. The Id proteins function as dominant-negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here, we review the role of E-proteins and their Id protein antagonists in lymphocyte proliferation and developmental progression. In addition, we discuss how E-protein activity and Id gene expression are regulated by T-cell receptor (TCR) and pre-TCR-mediated signalling.

摘要

螺旋-环-螺旋蛋白是淋巴细胞发育和功能的重要因子。特别是，E蛋白对于淋巴祖细胞向B细胞和T细胞谱系的定向分化至关重要。E蛋白受到螺旋-环-螺旋蛋白Id家族的负调控。Id蛋白通过抑制E蛋白结合DNA的能力，作为E蛋白的显性负性抑制剂发挥作用。在此，我们综述E蛋白及其Id蛋白拮抗剂在淋巴细胞增殖和发育进程中的作用。此外，我们还讨论了T细胞受体（TCR）和前TCR介导的信号传导如何调节E蛋白活性和Id基因表达。