Sonntag R W
Onkologie. 1979 Jun;2(3):129-33. doi: 10.1159/000214497.
Cis-diamminedichloroplatinum(II) (DDP) represents a new class of platinum compounds with cytostatic activity. Although the exact mechanism of action remains unknown, it is the most widely studied of these agents to date. The toxicology, metabolism, mode of application and clinical experience with this drug are presented and discussed. The value of DDP as monotherapy as well as in combination with other cytostatic agents, especially in the treatment of testicular cancer, as well as the possibilities of controlling its nephrotoxic effects are presented in greater detail.
顺二氯二氨铂（II）（DDP）是一类具有细胞生长抑制活性的新型铂化合物。尽管其确切作用机制尚不清楚，但它是迄今为止这类药物中研究最为广泛的。本文介绍并讨论了该药物的毒理学、代谢、应用方式及临床经验。更详细地阐述了DDP作为单一疗法以及与其他细胞生长抑制药物联合使用的价值，特别是在治疗睾丸癌方面，以及控制其肾毒性作用的可能性。
