（+）-指状内酯的全合成。
Total synthesis of (+)-dactylolide.
作者信息
Smith Amos B, Safonov Igor G
机构信息
Department of Chemistry, Monell Chemical Senses Center, and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
出版信息
Org Lett. 2002 Feb 21;4(4):635-7. doi: 10.1021/ol017271e.
PMID:11843610
Abstract
[reaction: see text] The total synthesis of the new cytotoxic marine macrolide (+)-dactylolide (1) has been achieved in nine steps from known vinyl bromide (-)-AB. In addition, (+)-zampanolide (2) has been converted to (+)-dactylolide (1) via thermolysis.
摘要
[反应：见正文] 新型细胞毒性海洋大环内酯类化合物（+）-达西醇内酯（1）已从已知的乙烯基溴化物（-）-AB经九步反应实现全合成。此外，（+）-赞帕诺内酯（2）已通过热解转化为（+）-达西醇内酯（1）。
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