关于海兔毒素a的合成：片段合成与偶联研究。

Toward the synthesis of peloruside a: fragment synthesis and coupling studies.

作者信息

Paterson Ian, Di Francesco M Emilia, Kühn Toralf

机构信息

University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

出版信息

Org Lett. 2003 Feb 20;5(4):599-602. doi: 10.1021/ol034035q.

DOI:10.1021/ol034035q

PMID:12583779

Abstract

[reaction: see text] The asymmetric synthesis of building blocks 3, 4, and 5, corresponding to C(12)-C(19), C(7)-C(11), and C(1)-C(6) segments of peloruside A, is reported, along with boron-mediated aldol coupling studies directed toward the assembly of the complete carbon skeleton of this microtubule-stabilizing macrolide.

摘要

[反应：见正文] 报道了与peloruside A的C(12)-C(19)、C(7)-C(11)和C(1)-C(6)片段相对应的结构单元3、4和5的不对称合成，以及针对这种微管稳定大环内酯类化合物完整碳骨架组装的硼介导的羟醛缩合反应研究。