Molecular linkage studies of bipolar disorders.
作者信息
Berrettini W H
机构信息
Department of Psychiatry and the Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19107, USA.
出版信息
Bipolar Disord. 2001 Dec;3(6):276-83. doi: 10.1034/j.1399-5618.2001.30603.x.
OBJECTIVES
To review the reports of linkage findings for bipolar disorder.
METHODS
Literature review of published linkage findings in bipolar disorder.
RESULTS
There are several regions of the human genome that have been implicated repeatedly by independent investigators. These include 4p16, 12q24, 18q22, 18p11, 21q21 and 22q11. Two of these regions (18p11 and 22q11) are also implicated in genome scans of schizophrenia, suggesting that these two distinct nosological categories may share some genetic susceptibility. This hypothesis can only be tested when the underlying genes are identified.
Zotero 插件