Escamilla Michael A, Zavala Juan M
University of Texas Health Science Center at San Antonio, South Texas Medical Genetics Research Center, 1214 Schunior St, Edinburg, TX 78539, USA.
Dialogues Clin Neurosci. 2008;10(2):141-52. doi: 10.31887/DCNS.2008.10.2/maescamilla.
Bipolar disorder especially the most severe type (type I), has a strong genetic component. Family studies suggest that a small number of genes of modest effect are involved in this disorder. Family-based studies have identified a number of chromosomal regions linked to bipolar disorder, and progress is currently being made in identifying positional candidate genes within those regions. A number of candidate genes have also shown evidence of association with bipolar disorder, and genome-wide association studies are now under way, using dense genetic maps. Replication studies in larger or combined datasets are needed to definitively assign a role for specific genes in this disorder. This review covers our current knowledge of the genetics of bipolar disorder, and provides a commentary on current approaches used to identify the genes involved in this complex behavioral disorder.
双相情感障碍，尤其是最严重的类型（I型），具有很强的遗传成分。家族研究表明，少数具有中等效应的基因与这种疾病有关。基于家族的研究已经确定了一些与双相情感障碍相关的染色体区域，目前在确定这些区域内的位置候选基因方面正在取得进展。一些候选基因也显示出与双相情感障碍相关的证据，并且目前正在使用密集遗传图谱进行全基因组关联研究。需要在更大或合并的数据集中进行复制研究，以明确特定基因在这种疾病中的作用。本综述涵盖了我们目前对双相情感障碍遗传学的认识，并对用于识别参与这种复杂行为障碍的基因的当前方法进行了评论。
