1999年至2000年期间从13个国家收集的流感嗜血杆菌和卡他莫拉菌临床分离株的抗菌药敏情况。

Antimicrobial susceptibilities of clinical isolates of Haemophilus influenzae and Moraxella catarrhalis collected during 1999-2000 from 13 countries.

作者信息

Turnak M R, Bandak S I, Bouchillon S K, Allen B S, Hoban D J

机构信息

Lilly Research Laboratories, Lilly Corporate Center, DC 6061, Indianapolis, IN 46285, USA.

出版信息

Clin Microbiol Infect. 2001 Dec;7(12):671-7. doi: 10.1046/j.1469-0691.2001.00344.x.

DOI:10.1046/j.1469-0691.2001.00344.x

PMID:11843908

Abstract

OBJECTIVE

To determine antimicrobial activity against Haemophilus influenzae and Moraxella catarrhalis.

METHODS

A central laboratory performed NCCLS susceptibility testing for all isolates and beta-lactamase and capsular serotype determinations for H. influenzae.

RESULTS

A total of 2712 H. influenzae and 1079 M. catarrhalis were collected. H. influenzae susceptibilities were >90% for amoxicillin/clavulanate, cefaclor, loracarbef, cefprozil, cefuroxime, ciprofloxacin, azithromycin and clarithromycin and were <80% for trimethoprim/sulfamethoxazole and ampicillin. 19.3% were beta-lactamase positive. The most common serotype was type-b (5.6%); 86.1% were nontypeable. M. catarrhalis had MIC90 within therapeutic range for all antimicrobials except ampicillin.

CONCLUSION

The conclusion of the study is that antimicrobials, except ampicillin and trimethoprim/sulfamethoxazole, remain good empiric choices against H. influenzae and M. catarrhalis.

摘要

目的

确定对流感嗜血杆菌和卡他莫拉菌的抗菌活性。

方法

一个中央实验室对所有分离株进行了美国国家临床实验室标准化委员会（NCCLS）药敏试验，并对流感嗜血杆菌进行了β-内酰胺酶和荚膜血清型测定。

结果

共收集到2712株流感嗜血杆菌和1079株卡他莫拉菌。流感嗜血杆菌对阿莫西林/克拉维酸、头孢克洛、氯碳头孢、头孢丙烯、头孢呋辛、环丙沙星、阿奇霉素和克拉霉素的敏感性>90%，对甲氧苄啶/磺胺甲恶唑和氨苄西林的敏感性<80%。19.3%为β-内酰胺酶阳性。最常见的血清型是b型（5.6%）；86.1%为不可分型。除氨苄西林外，卡他莫拉菌对所有抗菌药物的MIC90均在治疗范围内。