Dolganiuc A, Stavaru C, Anghel M, Baltaru D, Georgescu E, Olinescu A
Cantacuzino Institute, Bucharest, Romania.
Roum Arch Microbiol Immunol. 2000 Jan-Jun;59(1-2):43-53.
Polymorphonuclear neutrophils (PMN) play a central role in the elimination of most extracellular pathogenic microorganisms and any impairment of their functions therefore predisposes to defect immune defence. We investigated the migratory and phagocytic functions of the PMNs isolated from peripheral blood and synovial fluid of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). The results suggest that in RA the number and the migratory but not phagocytic capacity of synovial fluid (SF) neutrophils were enhanced, while in OA they were significantly decreased in synovial fluid cells comparatively with peripheral blood (PB). The migratory function of both PB and SF cells from RA patients was increased comparatively with that of the cells from OA patients. We found the different abnormal functions in synovial fluid neutrophils from RA and OA patients. These results may help to elucidate the underlying mechanism which leads to severe joint destruction and different susceptibility to infectious diseases in patients with rheumatic disorders.
多形核中性粒细胞（PMN）在清除大多数细胞外致病微生物过程中发挥核心作用，因此其功能的任何损害都易导致免疫防御缺陷。我们研究了从类风湿性关节炎（RA）和骨关节炎（OA）患者外周血和滑液中分离出的PMN的迁移和吞噬功能。结果表明，在RA中，滑液（SF）中性粒细胞的数量及其迁移能力增强，但吞噬能力未增强，而在OA中，与外周血（PB）相比，滑液细胞中的中性粒细胞数量显著减少。与OA患者的细胞相比，RA患者的PB和SF细胞的迁移功能均增强。我们发现RA和OA患者滑液中性粒细胞存在不同的异常功能。这些结果可能有助于阐明导致风湿性疾病患者严重关节破坏和对传染病易感性不同的潜在机制。
