Valdimarsdottir Heiddis B, Zakowski Sandra G, Gerin William, Mamakos Jean, Pickering Thomas, Bovbjerg Dana H
Biobehavioral Medicine Program, Cancer Prevention and Control, Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1130, New York 10029-6574, USA.
J Behav Med. 2002 Feb;25(1):51-65. doi: 10.1023/a:1013589718212.
This study examined the possibility that reactivity to acute stressors may be altered among women facing the chronic stress of being at familial risk for breast cancer. Sixteen healthy women with histories of breast cancer in their families (Risk Group) and 32 women at normal risk (Comparison Group) were exposed to 15 min of classic laboratory stressors. Seventeen women at normal risk were randomly assigned to nonstressful tasks (manipulation check). Self-reported distress, natural killer cell activity (NKCA), and NK cell numbers (percentage of CD3-CD16/56+ lymphocytes) were assessed before and after the tasks. Cardiovascular activity was assessed throughout the session. The tasks elicited increases in distress, heart rate, NKCA, and NK cells numbers in both experimental groups. Supporting study hypotheses, the Risk Group had larger increases in distress, heart rate, NKCA, and NK cell numbers. These findings raise the possibility that the chronic stress associated with familial cancer risk may have negative health consequences through changes in psychobiological reactivity.
本研究探讨了面临乳腺癌家族风险这一慢性压力的女性对急性应激源的反应性可能发生改变的可能性。16名有家族乳腺癌病史的健康女性（风险组）和32名正常风险女性（对照组）暴露于15分钟的经典实验室应激源中。17名正常风险女性被随机分配到无压力任务组（操作检查）。在任务前后评估自我报告的痛苦、自然杀伤细胞活性（NKCA）和NK细胞数量（CD3 - CD16/56 +淋巴细胞百分比）。在整个过程中评估心血管活动。任务在两个实验组中均引起痛苦、心率、NKCA和NK细胞数量增加。支持研究假设的是，风险组在痛苦、心率、NKCA和NK细胞数量方面有更大的增加。这些发现增加了这样一种可能性，即与家族性癌症风险相关的慢性压力可能通过心理生物学反应性的变化对健康产生负面影响。
