Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6.
作者信息
Li Lu, Itoh Masahiro, Ablake Maila, Macrì Battesimo, Bendtzen Klaus, Nicoletti Ferdinando
机构信息
Department of Internal Medicine, Kagawa Medical University, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
出版信息
Clin Immunol. 2002 Feb;102(2):135-7. doi: 10.1006/clim.2001.5155.
PMID:11846454
Abstract
We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.
摘要
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