Süleyman Halis, Akçay Fatih, Altinkaynak Konca
Department of Pharmacology, Atatürk University, Medical Faculty, Erzurum, Turkey.
Pharmacol Res. 2002 Feb;45(2):155-8. doi: 10.1006/phrs.2001.0933.
In the present study, we investigated the effects of nimesulide, indomethacin, naproxene, ibuprofen and diclofenac, at anti-inflammatory doses, on the rat gastric tissue (total number = 102). In addition, the effect of nimesulide at doses of 100, 300 and 500 mg kg(-1) on indomethacin-induced and ethanol-induced damage (ulcer) was examined. The potency of nimesulide was compared with that of ranitidine (at 150 mg kg(-1)). Results indicated that nimesulide did not produce any gastric damage. Additionally, it has a therapeutic effect on indomethacin- and ethanol-induced gastric lesions. Ulcer areas were measured in the rats given nonsteroidal anti-inflammatory drugs (NSAIDs). Nimesulide (at doses of 100, 300 and 500 mg kg(-1)) and ranitidine (at a dose of 150 mg kg(-1)) treated completely indomethacin-induced ulcer. The mean ulcer area was 21.9 +/- 8.9 mm(2)in the indomethacin-given control group. Nimesulide and ranitidine reduced the ethanol-induced gastric ulcer. The ulcer area was 114.3 +/- 10.3 mm(2) in the ethanol-given group and it was 4.5 +/- 4.8, 20.1 +/- 1.66, 15.16 +/- 4.05 mm(2) for nimesulide (at doses of 100, 300 and 500 mg kg(-1)), respectively, and 64.16 +/- 3.97 mm(2) for ranitidine.
在本研究中，我们研究了尼美舒利、吲哚美辛、萘普生、布洛芬和双氯芬酸在抗炎剂量下对大鼠胃组织的影响（总数 = 102）。此外，还检测了100、300和500 mg·kg⁻¹剂量的尼美舒利对吲哚美辛诱导和乙醇诱导损伤（溃疡）的影响。将尼美舒利的效力与雷尼替丁（150 mg·kg⁻¹）的效力进行了比较。结果表明，尼美舒利未造成任何胃损伤。此外，它对吲哚美辛和乙醇诱导的胃损伤具有治疗作用。对给予非甾体抗炎药（NSAIDs）的大鼠测量溃疡面积。尼美舒利（100、300和500 mg·kg⁻¹剂量）和雷尼替丁（150 mg·kg⁻¹剂量）完全治愈了吲哚美辛诱导的溃疡。给予吲哚美辛的对照组平均溃疡面积为21.9±8.9 mm²。尼美舒利和雷尼替丁减轻了乙醇诱导的胃溃疡。给予乙醇组的溃疡面积为114.3±10.3 mm²，尼美舒利（100、300和500 mg·kg⁻¹剂量）的溃疡面积分别为4.5±4.8、20.1±1.66、15.16±4.05 mm²，雷尼替丁的溃疡面积为64.16±3.97 mm²。
