Paulsen J E, Alexander J
Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway.
Anticancer Res. 2001 Sep-Oct;21(5):3281-4.
We studied the effects of extra dietary methionine on the formation and growth of intestinal adenomas in the Min (Apc+/-) mouse, which is a murine model of the human familial adenomatous syndrome. The AIN-76A diet was supplemented with 0.7% L-methionine from week 4 after birth and the animals were killed at week 8. The number of tumours in Min mice was apparently not affected by the addition of extra methionine. However, the dietary methionine supplementation increased the surface area of small intestinal tumours by 41% (p=0.009). In the colon, extra methionine did not affect tumour size. In conclusion, extra dietary methionine promotes the growth of adenomas in the small intestine of Min mice.
我们研究了额外添加膳食蛋氨酸对Min（Apc+/-）小鼠肠道腺瘤形成和生长的影响，Min（Apc+/-）小鼠是人类家族性腺瘤综合征的小鼠模型。从出生后第4周开始，在AIN-76A饮食中添加0.7%的L-蛋氨酸，并在第8周处死动物。额外添加蛋氨酸显然不会影响Min小鼠的肿瘤数量。然而，膳食补充蛋氨酸使小肠肿瘤的表面积增加了41%（p=0.009）。在结肠中，额外的蛋氨酸不影响肿瘤大小。总之，额外的膳食蛋氨酸可促进Min小鼠小肠腺瘤的生长。
