代谢型谷氨酸受体1基因敲除小鼠水平视动反应眼球运动适应性的丧失

Loss of adaptability of horizontal optokinetic response eye movements in mGluR1 knockout mice.

作者信息

Shutoh Fumihiro, Katoh Akira, Kitazawa Hiromasa, Aiba Atsu, Itohara Shigeyoshi, Nagao Soichi

机构信息

Department of Physiology, Jichi Medical School, Yakushiji 3311, Minamikawachi, Tochigi 329-0498, Japan.

出版信息

Neurosci Res. 2002 Feb;42(2):141-5. doi: 10.1016/s0168-0102(01)00308-x.

DOI:10.1016/s0168-0102(01)00308-x

PMID:11849733

Abstract

Metabotropic glutamate receptor subtype 1 (mGluR1) plays an essential role in the cerebellar long-term depression (LTD). We examined the dynamic characteristics and adaptability of horizontal vestibulo-ocular reflex (HVOR) and optokinetic response (HOKR) eye movements in mGluR1 knockout mice. A mild difference was seen in the HOKR/HVOR dynamics between the wild-type and mGluR1(-/-) mice. Exposure to 1 h of sustained screen oscillation, which induced HOKR adaptation in wild-type mice, induced no change in mutant mice. These results suggest that the mGluR1 plays an essential role in the adaptation of HOKR, and LTD underlies the adaptation of ocular reflexes.

摘要

代谢型谷氨酸受体1亚型（mGluR1）在小脑长时程抑制（LTD）中起关键作用。我们研究了mGluR1基因敲除小鼠水平前庭眼反射（HVOR）和视动反应（HOKR）眼球运动的动态特征和适应性。野生型和mGluR1（-/-）小鼠之间的HOKR/HVOR动态存在轻微差异。暴露于1小时的持续屏幕振荡中，这会在野生型小鼠中诱导HOKR适应，但在突变小鼠中未引起变化。这些结果表明，mGluR1在HOKR适应中起关键作用，并且LTD是眼反射适应的基础。