Nagao S
Department of Physiology, Faculty of Medicine, University of Tokyo, Japan.
Exp Brain Res. 1989;77(3):541-51. doi: 10.1007/BF00249607.
Sustained sinusoidal oscillation of a striped cylindrical screen around a stationary, alert pigmented rabbit with certain parameters (for 4 h. 5 degrees, 7.5 degrees, 10 degrees peak-to-peak, 0.1 or 0.2 Hz) adaptively modified not only the horizontal optokinetic reflex (HOKR) but also the horizontal vestibuloocular reflex (HVOR). The major effects thus obtained during 4 h were an increase in the HOKR gain by 0.23, and that of the HVOR gain by 0.18. Bilateral destruction of floccular Purkinje cells with microinjection of kainic acid abolished these effects on both HOKR and HVOR. Single unit activities of floccular Purkinje cells were recorded from the floccular areas related to horizontal eye movements (H-zone) with local stimulus effects. Most H-zone Purkinje cells normally exhibited modulation of simple spike discharge in phase with screen velocity and out of phase with turntable velocity. Sustained screen oscillation (7.5 degrees, 0.1 Hz) for 1 h increased the simple spike responses not only to screen but also to turntable oscillation. No such changes were observed in other floccular areas. These observations suggest that sustained optokinetic stimulations induce adaptation of HVOR through an interaction of retinal slip and head velocity signals within the flocculus or its related neuronal tissues.
在一定参数（4小时，峰峰值5度、7.5度、10度，0.1或0.2赫兹）下，使条纹圆柱屏幕围绕一只静止、警觉的有色家兔持续做正弦振荡，不仅能适应性地改变水平视动反射（HOKR），还能改变水平前庭眼反射（HVOR）。在4小时内由此获得的主要效应是，HOKR增益增加0.23，HVOR增益增加0.18。通过微量注射 kainic 酸对绒球浦肯野细胞进行双侧破坏，消除了对HOKR和HVOR的这些影响。从与水平眼动相关的绒球区域（H区）记录绒球浦肯野细胞的单位活动，并观察局部刺激效应。大多数H区浦肯野细胞通常表现出简单锋电位放电的调制，与屏幕速度同相，与转台速度异相。持续1小时的屏幕振荡（7.5度，0.1赫兹）不仅增加了对屏幕的简单锋电位反应，也增加了对转台振荡的反应。在其他绒球区域未观察到此类变化。这些观察结果表明，持续的视动刺激通过绒球或其相关神经组织内视网膜滑动和头部速度信号的相互作用，诱导HVOR的适应性变化。
