Harper J R, Orringer E P, Parker J C
Res Commun Chem Pathol Pharmacol. 1979 Nov;26(2):277-84.
Normal human red blood cells show a prompt, large increase in K permeability when their cytoplasmic Ca concentration is increased by various in vitro manipulations. Adriamycin, in concentrations greater than 0.02 mM, inhibits this response. Although the mechanism of adriamycin's action is not clear, experiments with dog red blood cells suggest that the drug inhibits passive Ca permeability. The importance of Ca-gated K movements in red blood cells is obscure, but in excitable tissues such ion currents play an important role in membrane repolarization. The influence of adriamycin on this ion conductance pathway may be related to the acute cardiotoxic and neurotoxic effects of the drug.
当通过各种体外操作使正常人红细胞的细胞质钙浓度升高时，其钾通透性会迅速大幅增加。阿霉素浓度大于0.02 mM时会抑制这种反应。尽管阿霉素的作用机制尚不清楚，但对狗红细胞的实验表明，该药物会抑制被动钙通透性。钙门控钾运动在红细胞中的重要性尚不清楚，但在可兴奋组织中，此类离子电流在膜复极化中起重要作用。阿霉素对这种离子传导途径的影响可能与该药物的急性心脏毒性和神经毒性作用有关。
