Sharara Ala I, Chedid Marwan, Araj George F, Barada Kassem A, Mourad Fadi H
Department of Internal Medicine, Box 11-0236/16B, American University of Beirut Medical Center, Beirut, Lebanon.
Int J Antimicrob Agents. 2002 Feb;19(2):155-8. doi: 10.1016/s0924-8579(01)00482-4.
The aim of this study was to determine the prevalence of antimicrobial resistance amongst Helicobacter pylori isolates cultured from gastric biopsies taken during routine endoscopies at the American University of Beirut Medical Center in Lebanon. Fifty-four consecutively recovered H. pylori isolates were tested against metronidazole, clarithromycin, tetracycline and amoxycillin using the epsilometer test. Resistance to metronidazole (MIC > 8 mg/l) was found in 29.5% of the isolates while resistance to clarithromycin (MIC > or =0.25 mg/l) and tetracycline (MIC > or =4 mg/l) was low (4 and 2%, respectively). All isolates were susceptible to amoxycillin (MIC < or =8 mg/l). These findings are comparable with those reported from Europe and the United States. The prevalence of metronidazole resistance in our study was lower than that from other parts of the Middle East and the developing world.
本研究的目的是确定从黎巴嫩贝鲁特美国大学医学中心常规内镜检查时采集的胃活检组织中培养出的幽门螺杆菌分离株的抗菌药物耐药率。使用埃普西隆测定法对连续获得的54株幽门螺杆菌分离株进行甲硝唑、克拉霉素、四环素和阿莫西林药敏试验。29.5%的分离株对甲硝唑耐药（最低抑菌浓度>8mg/l），而对克拉霉素（最低抑菌浓度>或=0.25mg/l）和四环素（最低抑菌浓度>或=4mg/l）的耐药率较低（分别为4%和2%）。所有分离株对阿莫西林敏感（最低抑菌浓度<或=8mg/l）。这些结果与欧洲和美国报道的结果相当。我们研究中甲硝唑耐药率低于中东其他地区和发展中世界。
