前列腺癌的11C-乙酸盐PET成像

11C-acetate PET imaging of prostate cancer.

作者信息

Oyama Nobuyuki, Akino Hironobu, Kanamaru Hiroshi, Suzuki Yuji, Muramoto Satoshi, Yonekura Yoshiharu, Sadato Norihiro, Yamamoto Kazutaka, Okada Kenichiro

机构信息

Department of Urology, Fukui Medical University, Fukui, Japan.

出版信息

J Nucl Med. 2002 Feb;43(2):181-6.

PMID:11850482

Abstract

UNLABELLED

11C-Acetate can act as a probe of tissue metabolism through entry into catabolic or anabolic metabolic pathways as mediated by acetyl-coenzyme A. The uptake of (11)C-acetate in prostate cancer was investigated to determine whether this tracer has potential in tumor identification.

METHODS

Twenty-two patients with prostate cancer underwent PET after intravenous administration of 740 MBq (11)C-acetate. Eighteen of the 22 patients were also investigated with (18)F-FDG PET. Standardized uptake values (SUVs) for each tumor were investigated for tracer activity at 10-20 min after (11)C-acetate and 40-60 min after (18)F-FDG administration.

RESULTS

Adenocarcinoma of the prostate showed variable uptake of (11)C-acetate, with SUVs ranging from 3.27 to 9.87. In contrast, SUVs for (18)F-FDG ranged from 1.97 to 6.34. By visual inspection, (11)C-acetate accumulation in primary prostate tumors was positive in all patients, whereas (18)F-FDG accumulation was positive in only 15 of 18 patients. (11)C-Acetate PET in a patient with lymph node metastasis showed high intrapelvic accumulation corresponding to metastatic sites. Similarly, 2 patients with bone metastases were (11)C-acetate avid.

CONCLUSION

(11)C-Acetate shows marked uptake in prostate cancer and is more sensitive in detection of prostate cancer than is (18)F-FDG PET. (11)C-Acetate represents a new tracer for detection of prostate cancer with PET, measuring radiopharmaceutical uptake pathways that are different from those measured by (18)F-FDG.

摘要

未标记

11C-醋酸盐可通过进入由乙酰辅酶A介导的分解代谢或合成代谢途径，作为组织代谢的一种示踪剂。研究了前列腺癌中（11）C-醋酸盐的摄取情况，以确定该示踪剂在肿瘤识别方面是否具有潜力。

方法

22例前列腺癌患者静脉注射740MBq（11）C-醋酸盐后接受PET检查。22例患者中的18例还接受了（18）F-FDG PET检查。在注射（11）C-醋酸盐后10 - 20分钟以及注射（18）F-FDG后40 - 60分钟，研究每个肿瘤的标准化摄取值（SUV）以了解示踪剂活性。

结果

前列腺腺癌对（11）C-醋酸盐的摄取各不相同，SUV范围为3.27至9.87。相比之下，（18）F-FDG的SUV范围为1.97至6.34。通过视觉检查，所有患者原发性前列腺肿瘤中（11）C-醋酸盐的积聚均为阳性，而（18）F-FDG的积聚在18例患者中仅15例为阳性。一名有淋巴结转移的患者进行的（11）C-醋酸盐PET显示盆腔内有与转移部位相对应的高积聚。同样，2例有骨转移的患者对（11）C-醋酸盐摄取明显。