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儿童药物不良反应的发生率：一项前瞻性研究。

Frequency of adverse drug reactions in children: a prospective study.

作者信息

Jonville-Béra Annie Pierre, Giraudeau Bruno, Blanc Pascal, Beau-Salinas Frèdèrique, Autret-Leca Elisabeth

机构信息

Department of Clinical Pharmacology and Regional Drug Monitoring Centre, University Hospital of Tours, 2 boulevard Tonellé, 37044 Tours Cedex, France.

出版信息

Br J Clin Pharmacol. 2002 Feb;53(2):207-10. doi: 10.1046/j.0306-5251.2001.01535.x.

DOI:10.1046/j.0306-5251.2001.01535.x
PMID:11851647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1874283/
Abstract

AIMS

To assess the frequency of adverse drug reactions (ADRs) in children in France.

METHODS

In a prospective study over a period of 1 week, we evaluated the incidence of ADRs (1) as a cause of admission to a regional children's hospital; (2) occurring during hospitalization in a regional children's hospital; and (3) as a cause of consultation with private paediatricians.

RESULTS

Four out of 260 children were admitted to the regional children's hospital for ADRs (1.53% [0.42, 3.89]) and six developed ADRs during hospitalization (2.64% [0.97, 5.66]), 4/428 attended the Accident and Emergency Department for ADRs (0.93% [0.25, 2.37]) and 8/1192 consulted a private paediatrician for ADRs (0.67% [0.29, 1.31]).

CONCLUSIONS

Our results are in agreement with the incidence of ADRs in children found in others countries.

摘要

目的

评估法国儿童药物不良反应（ADR）的发生频率。

方法

在一项为期1周的前瞻性研究中，我们评估了ADR的发生率：（1）作为地区儿童医院入院的原因；（2）在地区儿童医院住院期间发生；（3）作为咨询私立儿科医生的原因。

结果

260名儿童中有4名因ADR入住地区儿童医院（1.53% [0.42, 3.89]），6名在住院期间发生ADR（2.64% [0.97, 5.66]），4/428因ADR前往急诊科就诊（0.93% [0.25, 2.37]），8/1192因ADR咨询私立儿科医生（0.67% [0.29, 1.31]）。

结论

我们的结果与其他国家儿童ADR的发生率一致。

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