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A型肉毒毒素在痉挛性脑瘫患儿骨科手术中的痉挛管理应用

Botulinum toxin type A management of spasticity in the context of orthopaedic surgery for children with spastic cerebral palsy.

作者信息

Graham H K

机构信息

Orthopaedic Surgery, University of Melbourne, Orthopaedic Surgery, Murdoch Children's Research Institute, Royal Children's Hospital, Hugh Williamson Gait Laboratory, Australia.

出版信息

Eur J Neurol. 2001 Nov;8 Suppl 5:30-9. doi: 10.1046/j.1468-1331.2001.00036.x.

Abstract

Cerebral palsy is the most common cause of physical disability affecting children in developed countries. Although cerebral palsy is, by definition, a 'static encephalopathy' the associated musculoskeletal pathology is progressive and current definitions are therefore somewhat inadequate. Understanding the stages of the musculoskeletal pathology is fundamental to understanding current management strategies, including spasticity management, strengthening programmes and deformity correction by orthopaedic surgery. In this review, a number of new management strategies are described, in which spasticity management by intramuscular injections of botulinum toxin type A and deformity correction, by orthopaedic surgery, are combined.

摘要

脑瘫是发达国家中影响儿童的最常见身体残疾原因。虽然从定义上讲,脑瘫是一种“静态脑病”,但其相关的肌肉骨骼病理是进行性的,因此目前的定义在某种程度上并不充分。了解肌肉骨骼病理的阶段是理解当前管理策略的基础,这些策略包括痉挛管理、强化训练计划以及通过矫形外科手术进行畸形矫正。在这篇综述中,描述了一些新的管理策略,其中将通过肌肉注射A型肉毒杆菌毒素进行痉挛管理与通过矫形外科手术进行畸形矫正相结合。

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